I don't know how the iFlash Quad adapters work across multiple cards (even their own web site is lacking in this respect), but there are two possibilities:
1) stripe data blocks across all installed cards. So installing an additional card means everything else stops working (I don't find this likely)
2) linearly combine all installed cards. So (eg) the second card probably won't be touched until the first runs out of space.
In the first scenario you'd have to do a complete format/reinstall (except the bootloader) as the stripe offsets for any existing data gets scrambled out of existence.
In the second scenario, from the OS perspective the "drive" just got bigger, but all existing data remains in the same place. So you'd only need to extend the existing partition to make use of the rest of the space, no reinstall needed. You can use something like gparted to accomplish this.
Keep in mind that in either scenario, with every card you add you double the probability of failure, and if any of the cards fail (especially the first, which will inevitably see the most wear) you will experience (most likely total) data loss.