possibly, idk if there is a software workaround though the power down button is definitely of either higher priority or a different pin though from what i can tell. still wouldn't be much help being that we would need 2 extra buttons for rockboy to be compatible and we might even need 6 extra if gameboy accepts multiple D-pad inputs at once im not really sure about that
my biggest question now is just whether or not the creative zen has OTG support, kinda seems unlikely