it appears that this message is initiated when the E280 is plugged in to the USB port. Something starts the "Autorun.exe" program and the first error message with the 'dshf43erd' title bar and the 'runtime error 70' comes from the autorun.exe. process which starts from the sansa device root directory. The next dialog error message about the setup files being corrupted comes from the process zende.exe which comes from /windows/system32.
Hope this helps,
Joel